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The liver plays a vital role in human health, regulating metabolism and blood nutrient levels, filtering toxins, and synthesizing important proteins for blood clotting. It is also sensitive to changes in diet, behavior, and environmental factors, meaning it will also respond to changes in gravity. Despite considerable research into liver metabolism and function aboard the International Space Station (ISS), unanswered questions remain about how liver cells sense gravity and convert mechanical stress into metabolic responses.

