No matter what mode of transportation you take for a long trip, at some point, you’ll have to refuel. For cars, this could be a simple trip to a gas station, while planes, trains, and ships have more specialized refueling services at their depots or ports. However, for spacecraft, there is currently no refueling infrastructure whatsoever. And since the fuel spacecraft use must be stored cryogenically, and the tanks the fuel is stored in are constantly subjected to the thermal radiation from the Sun, keeping enough fuel in a tank for a trip to Mars with astronauts is currently infeasible. Luckily, NASA is currently working on it and recently released a detailed look at some of that work on a blog on their website.